Overview

Optimization-based analysis of metabolic networks has allowed to design metabolic engineering strategies aiming at enhancing the production of a target of interest. Here, we present a comprehensive tool for the calculation of a stoichiometric capacitance allowing for increasing the maximum value the production of a given product can take.

MeDUSA provides an extensive sage-based package which, given a metabolic network and an objective function, (i) computes a stoichiometric capacitance, (ii) investigates the effect of adding the calculated stoichiometric capacitance and (iii) visualizes the changes in the importance of metabolic reactions for performing the network objective.